Tourette syndrome (TS) is a chronic neurological disorder of unknown cause characterized by recurrent motor and vocal tics. : This study suggests that FMT may ameliorate TS by promoting 5-HT secretion, and it provides new insights into the underlying mechanisms of FMT as a treatment for TS. In the probiotic and FMT experiments, the serum 5-HT levels significantly increased in TSMO that received probiotics (KS = 1.423, P = 0.035) and in those transplanted with feces from CONH ( W = 336.5, P = 0.046) compared with TSMO without transplantation. Compared with non-transplanted TSMO, the symptoms of those transplanted with feces from CONH were alleviated ( W = 336, P = 0.046). A significant increase in Turicibacteraceae and Ruminococcaceae in TSMO after FMT was observed (P < 0.05). : A total of 18 discriminative microbial signatures (linear discriminant analysis score > 3) that varied significantly between TS and healthy mice (CONH) were identified. Differences between groups were analyzed using Mann-Whitney U test and Kolmogorov-Smirnov (KS) tests. 16S rRNA sequencing, behavioral observation, and serum serotonin (5-HT) assay were performed. Fecal specimens were collected 3 weeks after FMT. Mice were grouped into eight groups and were subjected to FMT with feces from children or mice with or without TS, or were given probiotics. : TS mice model (TSMO) (n = 80) were established with 3,3′-iminodipropionitrile, and 80 mice were used as controls. Herein, FMT effects and mechanisms were explored in a TS mouse model.
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A small clinical trial showed that fecal microbiota transplantation (FMT) may alleviate TS symptoms in children. Therefore, the gut microbiota plays an important role in some mental illnesses. Gut microbiota can affect central physiology and function via the microbiota–gut-brain axis. : Tourette syndrome (TS) is a neuropsychiatric disorder with onset in childhood that warrants effective therapies.
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Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website ( This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. Supplemental digital content is available for this article. Fecal transplantation can alleviate tic severity in a Tourette syndrome mouse model by modulating intestinal flora and promoting serotonin secretion.
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How to cite this article: Li H, Wang Y, Zhao C, Liu J, Zhang L, Li A. 1Department of Gastroenterology, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, ChinaĢDepartment of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Chancheng District, Foshan, Guangdong 528000, ChinaģJinan Institute of Paediatric Medicine, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, ChinaĤMicrobiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250002, ChinaĥDepartment of Traditional Chinese Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China.Ĭorrespondence to: Anyuan Li, Department of Traditional Chinese Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, ChinaE-Mail:
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